|
KMID : 0043320110340081297
|
|
Archives of Pharmacal Research
2011 Volume.34 No. 8 p.1297 ~ p.1300
|
|
|
One new pregnane glycoside from the seeds of cultivated Brucea javanica
|
|
Liu Jie Qing
Wang Cui Fang
Li Xing Yao
Chen Jian Chao
Li Yan
Qiu Ming Hua
|
|
|
Abstract
|
|
|
|
A new pregnane glycoside, named (20R)-O-(3)-β-D-glucopyranosyl-(1→2)-α-L-arabinopyranosyl-pregn-5-en-3β,20-diol (1), and seven known compounds, brusatol (2), bruceine B (3), bruceine D (4), yadanziolide A (5), bruceine E (6), yadanzioside G (7), and yadanzioside B (8), were isolated from the cultivated dry seeds of Brucea javanica. The structure of 1 was elucidated on the basis of 1D- and 2D-NMR spectroscopic analyses. Their inhibitory effects on tumor cells were also tested. Compound 1 was slightly active against HL-60, SMMC-7721, A-549, and MCF-7 tumor cells. Compounds 2 and 3 demonstrated significant inhibitory activities against all tested cells. These results indicate that cultivated B. javanica could replace the wild plant as an antitumor plant resource.
|
|
|
KEYWORD
|
|
|
Brucea javanica, Pregnane glycoside, Antitumor activity, Brusatol
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
  
|
|